Sustainable Flourishing

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Developments in bioengineering keep moving the needle between reality and science fiction. From genetic editing with the CRISPR-Cas system and growing functioning organoids in petri dishes to brain cells on microchips — scientists continue to surprise us with cutting-edge inventions.

Now, for the first time, researchers from the Department of Condensed Matter Physics at the Jožef Stefan Institute in Ljubljana, Slovenia, established a method to 3D print microscopic structures inside living human cells. To demonstrate the detail and versatility of the technology, they printed a tiny elephant, alongside other microscopic geometric objects and barcodes for cell labeling, into the interior of a cell.

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Where did cannabis compounds like THC, CBD, and CBC come from? Scientists at Wageningen University & Research have now provided the first experimental proof showing how cannabis developed the ability to make these well-known cannabinoids. Along the way, the team also created enzymes that could be useful for producing cannabinoids through biotechnology, especially for medical use.

Their findings were published in the scientific journal Plant Biotechnology Journal. To reach these conclusions, the researchers rebuilt enzymes that no longer exist today but were active millions of years ago in early ancestors of the cannabis plant. Enzymes are essential to cannabinoid production in cannabis, driving the chemical reactions that create these bioactive compounds with recognized medicinal potential.

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A recent study published in Cell Reports Medicine demonstrated that, under the right conditions, the brain can repair itself using a compound that restores NAD+ levels.

Although conducted in animal models, this research offers a ray of hope for someday treating Alzheimer’s disease (AD). It serves as a vital reminder that we must never abandon hope or withhold care from anyone, no matter how fragile their medical condition or health.

For decades, AD has long been thought to be permanent and irreversible. Yet, researchers from Case Western Reserve University, University Hospitals Cleveland Medical Center, and the Louis Stokes VA Medical Center in Cleveland found that restoring proper levels of the critical cellular energy molecule NAD+ not only prevented AD-like pathology in mice but also reversed advanced cognitive decline and brain injury.

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Researchers from the University of Colorado Boulder, University of Arizona, and Sandia National Laboratories have developed a new device that generates controlled vibrations on the surface of a microchip. These waves could help future smartphones become thinner, faster, and more efficient at handling wireless signals.

According to the research paper, they have developed a surface acoustic wave (SAW) phonon laser that can create “the tiniest earthquakes imaginable”. Instead of light, this laser sends mechanical waves that skim along the surface of a material.

Phones already rely on surface acoustic waves to clean up messy wireless signals, but it requires multiple components. This new approach aims to compress much of that work into a single, compact chip, freeing up space while improving performance.

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A tiny, premature baby, who weighed less than a bag of sugar when she was born, has finally been able to leave the hospital, just in time for Christmas.

Baby Desire was born 18 weeks prematurely to first-time parents Omotola and Samuel Joseph, after her mum went into labour unexpectedly in July. The little premature baby weighed only 13 ounces, or 375 grams, when she was born, and so had to spend time in the care of doctors and nurses at a neonatal intensive care unit (NICU) while she developed.

“Before she was born, we prepared our minds for what might happen. She was just so tiny, fitting entirely in the palm of my hand”, mum Omotola said.

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A team of researchers in China has just pulled the curtain back on a new sodium-sulfur battery design that could fundamentally change the math on energy storage. By leaning into the very chemistry that has historically made sulfur a headache for engineers, they have managed to build a cell that is incredibly cheap to make but still packs a massive energy punch.

The design, which is currently being tested in the lab, uses dirt-cheap ingredients: sulfur, sodium, aluminum, and a chlorine-based electrolyte. In early trials, the battery hit energy densities over 2,000 watt-hours per kilogram – a figure that blows today’s sodium-ion batteries out of the water and even gives top-tier lithium cells a run for their money.

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As he addressed an audience of virologists from China, Australia, and Singapore at October’s Pandemic Research Alliance Symposium, Wei Zhao introduced an eye-catching idea.

The gene-editing technology Crispr is best known for delivering groundbreaking new therapies for rare diseases, tweaking or knocking out rogue genes in conditions ranging from sickle cell disease to hemophilia. But Zhao and his colleagues at Melbourne’s Peter Doherty Institute for Infection and Immunity have envisioned a new application.

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Move over, colonoscopies — researchers writing in ACS Sensors report that they have created tiny microspheres filled with bacteria that can sense the presence of blood, a key sign of gastrointestinal disease. These microspheres function like miniature “pills” that are swallowed and include magnetic particles so they can be easily collected from stool. After passing through mouse models with colitis, the sensors detected gastrointestinal bleeding within minutes. The team notes that the same bacterial system could eventually be engineered to identify other gut-related conditions.

“This technology provides a new paradigm for rapid and non-invasive detection of gastrointestinal diseases,” says Ying Zhou, a co-author of the study.

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“AI-powered digital twins mark a major evolution in the future of manufacturing, enabling real-time visualization of the entire production line, not just individual machines,” says Indranil Sircar, global chief technology officer for the manufacturing and mobility industry at Microsoft. “This is allowing manufacturers to move beyond isolated monitoring toward much wider insights.”

A digital twin of a bottling line, for example, can integrate one-dimensional shop-floor telemetry, two-dimensional enterprise data, and three-dimensional immersive modeling into a single operational view of the entire production line to improve efficiency and reduce costly downtime. Many high-speed industries face downtime rates as high as 40%, estimates Jon Sobel, co-founder and chief executive officer of Sight Machine, an industrial AI company that partners with Microsoft and NVIDIA to transform complex data into actionable insights. By tracking micro-stops and quality metrics via digital twins, companies can target improvements and adjustments with greater precision, saving millions in once-lost productivity without disrupting ongoing operations.

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Memory problems may not be an unavoidable part of getting older. New findings from Virginia Tech reveal that age-related memory loss stems from specific molecular changes in the brain, and that fine-tuning these processes can help restore memory function.

In two complementary studies, Timothy Jarome, an associate professor in the College of Agriculture and Life Sciences’ School of Animal Sciences, and his graduate students used advanced gene-editing tools to target these molecular changes and improve memory performance in older rats. Rats are commonly used as models for understanding how memory declines with age.

“Memory loss affects more than a third of people over 70, and it’s a major risk factor for Alzheimer’s disease,” said Jarome, who also serves in the School of Neuroscience. “This work shows that memory decline is linked to specific molecular changes that can be targeted and studied. If we can understand what’s driving it at the molecular level, we can start to understand what goes wrong in dementia and eventually use that knowledge to guide new approaches to treatment.”

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Detailed map of the genome one pixel per nucleotide. Credit: Radcliffe Department of Medicine

Scientists from Oxford’s Radcliffe Department of Medicine have achieved the most detailed view yet of how DNA folds and functions inside living cells, revealing the physical structures that control when and how genes are switched on.

Using a new technique called MCC ultra, the team mapped the human genome down to a single base pair, unlocking how genes are controlled, or, how the body decides which genes to turn on or off at the right time, in the right cells. This breakthrough gives scientists a powerful new way to understand how genetic differences lead to disease and opens up fresh routes for drug discovery.

“For the first time, we can see how the genome’s control switches are physically arranged inside cells, said Professor James Davies, lead author of the study published in the journal Cell titled “Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.”

The wanna-be world czar Bill Gates signaled to the world that the climate change hoax jig was up after admitting “The doomsday outlook is causing much of the climate community to focus too much on near-term emissions goals, and it’s diverting resources from the most effective things we should be doing to improve life in a warming world. The biggest problems are poverty and disease, just as they always have been.”

This signals a potential shift in globalist strategy from promising to save the world from human greed and the brown people from the white devil, they’re going to go back to the basics, economic class. President Trump wasn’t letting Gates surrender so gently, however.

He quipped back, “I (WE!) just won the War on the Climate Change Hoax. Bill Gates has finally admitted that he was completely WRONG on the issue,” he added. “It took courage to do so, and for that we are all grateful. MAGA!!!”

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President Donald Trump said opponents of the “climate change hoax” had won the struggle after Bill Gates said supporters should pivot their efforts.

Gates has been a longtime proponent of policies to fight climate change, but on Monday he took a far more moderate tone that accepted the survivability of slightly higher global temperatures.

‘Bill Gates has finally admitted that he was completely WRONG on the issue.’

“I (WE!) just won the War on the Climate Change Hoax,” the president wrote on his Truth Social account.

“Bill Gates has finally admitted that he was completely WRONG on the issue,” he added. “It took courage to do so, and for that we are all grateful. MAGA!!!”

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A squishy robotic “eye” can focus automatically in response to light, without any external power. The ultrapowerful robotic lens is sensitive enough to distinguish hairs on an ant’s leg or the lobes of a pollen grain.

The lens could usher in “soft” robots with powerful vision that would not need electronics or batteries to operate. Soft robotics can be used in a wide range of different applications, from wearable technology that can integrate with the human body to autonomous devices that can operate in uneven terrain or hazardous spaces, said study first author Corey Zheng, a doctoral student in biomedical engineering at the Georgia Institute of Technology. Traditional, electrically powered robots use rigid sensors and electronics to see the world.

 

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Scientists have developed a promising cancer therapy that uses LED light and ultra-thin flakes of tin to eliminate cancer cells while protecting healthy tissue. Unlike traditional chemotherapy and other invasive treatments, this new method avoids the painful side effects patients often endure.

The breakthrough comes from a partnership between The University of Texas at Austin and the University of Porto in Portugal, made possible through the UT Austin Portugal Program. The collaboration aims to make light-based cancer therapies more accessible and affordable. Current versions of these treatments rely on expensive materials, specialized lab setups, and powerful lasers that can sometimes damage surrounding tissue. By switching to LEDs and introducing tin-based “SnOx nanoflakes” (“Sn” is the chemical symbol for tin), the researchers have created a safer and potentially low-cost alternative.

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A RARE blue parrot declared extinct in the wild has hatched for the first time at a conservation centre, sparking new hope for the species.

The Spix’s macaw chick was born at the Centre for the Conservation of Endangered Bird Species in Pairi Daiza, a zoo in Cambron-Casteau, Belgium, on September 21.

It is the first chick of its species to hatch at the park after 100 previous eggs failed to be fertilised, marking a major breakthrough in an international breeding programme to save the world’s rarest parrot.

The zoo said: “Egg 101 is a true miracle of life, the result of years of effort and patience,” and described it as “a birth more precious than gold.”

Specialists decided to remove the egg from its inexperienced parents before it hatched to increase the chick’s chances of survival.

Its caretaker Thomas Biagi said having to feed the chick every two hours was exhausting but motivating because “we’re literally holding the future of one of the world’s most endangered species in our hands.”

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Imagine a future where the internet isn’t just fast, it’s fundamentally different. Where information doesn’t travel through cables in bits and bytes, but dances across space in entangled photons, instantaneously linking quantum computers continents apart. In this shimmering vision of tomorrow, the backbone of communication is no longer copper or fiber; it’s quantum light.

At the heart of this revolution is a peculiar phenomenon known as squeezed light, and a team of researchers from the U.S. Department of Energy’s Fermi National Accelerator Laboratory and the California Institute of Technology believes it may be the key to unlocking scalable quantum networks. Their latest study, led by Fermilab scientist Alexandru Macridin, marks a pivotal step toward building a quantum internet, one that could transform scientific research, cryptography, and computing itself.

Quantum networks rely on entangled qubits: pairs of quantum bits that remain mysteriously connected, no matter how far apart they are. In quantum physics, entanglement is the ghostly thread that links particles across space, such that a change in one instantly affects the other. It’s a phenomenon Einstein famously referred to as “spooky action at a distance,” and it forms the cornerstone of quantum communication.

from www.techexplorist.com

Bacteria - Wikipedia

Bacteria - Wikipedia

Bacteria hidden inside tumors could help beat cancer– www.sciencedaily.com
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An international team of scientists led by researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and the University of Cologne have discovered that microbes associated with tumors produce a molecule, which can control cancer progression and boost the effectiveness of chemotherapy.

Most people are familiar with the microbes on our skin or in our gut, but recent discoveries have revealed that tumors also host unique communities of bacteria. Scientists are now investigating how these tumor-associated bacteria can affect tumor growth and the response to chemotherapy.

New research, published online in Cell Systems on September 10, 2025, provides a significant breakthrough in this field, identifying a powerful anti-cancer metabolite produced by bacteria associated with colorectal cancer. This finding opens the door to new strategies for treating cancer, including the development of novel drugs that could make existing therapies more potent.

The researchers used a sophisticated large-scale screening approach to test over 1,100 conditions in a type of microscopic worm called C. elegans. Through this, they found that the bacteria E. coli produced a molecule called 2-methylisocitrate (2-MiCit) that could improve the effectiveness of the chemotherapy drug 5-fluorouracil (5-FU).

Study finds that by age 3 kids prefer nature's fractal patterns ...

Study finds that by age 3 kids prefer nature's fractal patterns ...

Mathematicians Discover Prime Number Pattern in Fractal Chaos– www.scientificamerican.com
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Prime numbers are sometimes called math’s “atoms” because they can be divided by only themselves and 1. For two millennia, mathematicians have wondered if the prime numbers are truly random, or if some unknown pattern underlies their ordering. Recently number theorists have proposed several surprising conjectures on prime patterns—in particular, probabilistic patterns that show up in large groups of the mathematical atoms.

The patterns in the primes trace back to an 1859 hypothesis involving the legendary Riemann zeta function. Mathematician Bernhard Riemann derived a function that counts the number of primes up to a number x. It includes three main ingredients: a smooth estimate, a set of corrective terms coming from the Riemann zeta function, and a small error term.

Much has been written about the Riemann zeta function, but the most important thing to know is that it provides a correction to the smooth estimate. To do so, it takes on a wavy pattern, sometimes raising the count, sometimes lowering it. These corrective oscillations are determined by the locations of the zeros of the Riemann zeta function. In fact, the celebrated Riemann hypothesis claims that all such zeros lie on a “critical line” where the real part equals 12.

A single dose of psilocybin may rewire the brain for lasting relief– www.sciencedaily.com
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Researchers at Penn Medicine have identified specific brain circuits that are impacted by psilocybin — the active compound found in some psychedelic mushrooms — which could lead to new paths forward for pain and mental health management options. Chronic pain affects more than 1.5 billion people worldwide and is often deeply entangled with depression and anxiety, creating a vicious cycle that amplifies suffering and impairs quality of life. The study from the Perelman School of Medicine at the University of Pennsylvania- published today in Nature Neuroscience- offers new insight into ways to disrupt this cycle.

“As an anesthesiologist, I frequently care for people undergoing surgery who suffer from both chronic pain and depression. In many cases, they’re not sure which condition came first, but often, one makes the other worse,” said Joseph Cichon, MD, PhD, an assistant professor of Anesthesiology and Critical Care at Penn and senior author of the study. “This new study offers hope. These findings open the door to developing new, non-opioid, non-addictive therapies as psilocybin and related psychedelics are not considered addictive.”