00 First Filter

The first person to get a Neuralink chip in his brain says he met Elon Musk on the day of his surgery: ‘He’s a cool dude’– fortune.com
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Attendees at Fortune’s Brainstorm Tech conference last week witnessed a demonstration of both technological innovation and human resilience when Noland Arbaugh, the first human recipient of Neuralink’s brain-computer interface (BCI) chip, played chess using only his thoughts. Arbaugh also shared candid insights into his pioneering journey, including his memorable first encounter with Neuralink’s cofounder and the world’s richest man, Elon Musk.

Arbaugh’s journey began with a diving accident at a summer camp in 2016, which left the former Texas A&M student paralyzed from the shoulders down and largely dependent on his family. For years, Arbaugh lived what he describes as a severely limited existence.

“I would stay up all hours of [the] night, just sleep in whenever, wake up whenever I wanted to because I didn’t really have anything planned, didn’t have anything going on in my life,” he told Fortune senior writer Jessica Mathews during their conversation. Arbaugh said he left his house only a couple of times per year.

“Before Neuralink, I thought I would never travel again,” he said. “[I] thought I would just stay in my room.”

JD Foster: Trump Is Right In Calling For The End To Quarterly Reporting– dailycaller.com
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Sometimes, it’s the little things. Sometimes, it’s bigger things. This time it’s the quarterly earnings report required by law of America’s publicly traded companies. And it’s President Trump suggesting on Truth Social that we should do away with quarterly earnings statements in favor of bi-annual statements. He’s right.

The Securities and Exchange Commission (SEC) requires publicly traded companies to report their earnings quarterly. In contrast, the hyper-regulative European Union and United Kingdom require six-month reporting, though corporations are allowed to make quarterly statements if they want.

Quarterly reporting is just one of the hundreds of rules U.S. publicly traded companies face that privately held companies don’t. Nearly all of these rules make some sense in isolation, but collectively they represent an enormous burden, one effect of which is that even as the American economy has grown steadily over the years, the number of publicly traded companies had fallen by half. Houston, we have a problem.

Quarterly reporting is expensive to the corporation and a major time burden for senior management. These are relative nuisances.

Drug shows promise against aggressive cancers in trial– www.futurity.org
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An immunotherapy drug eliminated aggressive cancers in a clinical trial, researchers report.

Over the past 20 years, a class of cancer drugs called CD40 agonist antibodies have shown great promise—and induced great disappointment. While effective at activating the immune system to kill cancer cells in animal models, the drugs had limited impact on patients in clinical trials and caused dangerously systemic inflammatory responses, low platelet counts, and liver toxicity, among other adverse reactions—even at a low dose.

But in 2018, the lab of Rockefeller University’s Jeffrey V. Ravetch demonstrated it could engineer an enhanced CD40 agonist antibody so that it improved its efficacy and could be administered in a manner to limit serious side effects.

The findings came from research on mice, genetically engineered to mimic the pathways relevant in humans. The next step was to have a clinical trial to see the drug’s impact on cancer patients.

Now the results from the phase 1 clinical trial of the drug, dubbed 2141-V11, appear in Cancer Cell. Of 12 patients, six patients saw their tumors shrink, including two who saw them disappear completely.

“Seeing these significant shrinkages and even complete remission in such a small subset of patients is quite remarkable,” says first author Juan Osorio, a visiting assistant professor in Ravetch’s Leonard Wagner Laboratory of Molecular Genetics and Immunology and a medical oncologist at Memorial Sloan Kettering Cancer Center.

 

 

Trauma focused therapy shows promise for children with PTSD– cosmosmagazine.com
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A new study has demonstrated how a specific form of therapy can help improve symptoms in children living with post-traumatic stress disorder (PTSD), a mental health condition that develops after witnessing or experiencing a traumatic event.

Researchers from the University of East Anglia in Norwich, England have examined the effectiveness of trauma-focused cognitive behavioural therapy (CBT) for treating young children who have been subjected to abuse, violence or serious accidents.

CBT is a treatment for mental health conditions that helps individuals to identify any negative thoughts they may have and teaches them self-help strategies to challenge and reduce these unhelpful thought patterns.

According to the World Health Organisation, roughly 3.9% of the world’s population has experienced PTSD at some stage in their life. While trauma-focused CBT is already used to help treat the disorder in adults, children who experience multiple traumas are often considered harder to treat.

“Recent research has shown that more than 7% of young people in the UK will have developed PTSD at some point by the age of 18,” says Richard Meiser-Stedman, the lead researcher of the study from the University of East Anglia, UK.

Trump’s lowered 15% tariff on cars from Japan to take effect Tuesday– japantoday.com
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U.S. President Donald Trump’s lowered tariff of 15 percent on automobiles from Japan will take effect Tuesday, the Commerce Department said, about four months after his aggressive trade agenda started damaging the industrial backbone of one of Washington’s key allies.

The department announced the timing of the adjustment on Monday. The U.S. tariff rate for foreign-origin cars rose to 27.5 percent after Trump imposed in April an additional auto tariff on national security grounds, squeezing the margins of Japanese automakers and other manufacturers.

The reduced tariff is part of a trade deal the Trump administration struck on July 22 with Japan, which in return has committed to investing heavily in the United States and increasing imports of American agricultural products during the president’s nonconsecutive second term.

Trump signed an executive order on Sept. 4 formally implementing the trade agreement, which also granted Japan special treatment on what he calls “reciprocal” tariffs.

The department’s notice to be published Tuesday said that as agreed by the two countries, Trump’s additional 25 percent tariff imposed in May on major auto parts, including engines and transmissions, will also be cut to 15 percent for those coming from Japan.

Blood proteins tied to Alzheimer’s disease– www.futurity.org
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Researchers have found new clues in the blood that could help explain why Alzheimer’s disease develops and how it affects memory.

The study in Nature Aging examined blood samples from more than 2,100 individuals across four large research cohorts. Using advanced tools, scientists measured thousands of proteins in the blood and linked them to changes in the brain and thinking ability.

Traditionally, doctors have focused on sticky amyloid plaques in the brain as a hallmark of Alzheimer’s.

But the new research shows that many other processes are also at play. The team found that proteins related to the immune system, protein disposal, energy use, and the body’s support structure (called the extracellular matrix) were tied to memory and thinking problems.

Importantly, not all of these changes could be explained by known Alzheimer’s brain changes, suggesting that factors outside the brain—like processes in blood and other organs—may contribute to the disease.

“Many of the proteins we found in blood are not directly tied to what we see in the brain after death,” says Erik Johnson, senior author, physician, and researcher at Emory University’s Goizueta Alzheimer’s Disease Research Center.

 

 

Both the Left and the Right are Targeted by Political Violence. Who Perpetrates It? – Mother Jones– www.motherjones.com
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Conservative activist Charlie Kirk’s gruesome killing last week was both a striking visual of our nation’s intensifying polarization and, by some counts, a catalyst for it to intensify more. Even before a suspect had been identified, there was a knee-jerk reaction among some Republicans to blame the Democratic Party for his death. Some even called for retribution.

Importantly, we do not yet—and may never—know the motive, or constellation of motivations, that drove Kirk’s alleged shooter, who has been identified as 22-year-old Tyler Robinson. But we do know that targets of political violence exist across the political spectrum.

Consider some of the recent events of political violence:

  • Just three months ago, Democratic Minnesota state representative Melissa Hortman and her husband Mark were assassinated in their home. Another member of the Minnesota Democratic-Farmer-Labor Party and his wife were also repeatedly shot and wounded; the suspect apprehended for these crimes had a list of dozens of potential targets, including other Democrats and abortion rights advocates.
  • In August, a law enforcement officer died amid a shooting that was directed at the Centers for Disease Control and Prevention; the shooter had blamed his depression on the Covid vaccine.
  • In May, two staffers of the Israeli Embassy in Washington, DC, were fatally shot; the suspect in that case previously expressed strong opposition to Israel’s aggression in Palestine.
  • In April, the residence of Pennsylvania Governor Josh Shapiro was set on fire in what prosecutors are calling an attempted murder. The fire took place a few hours after Shapiro, a Jewish Democrat, celebrated Passover.

YouTube’s paid creators $100 billion in four years– mashable.com
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There’s a reason creators often try to migrate their audience to YouTube: It pays.

The Google-owned streaming giant said it has paid out more than $100 billion in the last four years to creators, artists, and media companies. YouTube announced the figure at the Made on YouTube event on Tuesday.

“We didn’t just create a platform. We built an economy,” said YouTube CEO Neal Mohan.

As Mashable reported earlier this year, creator jobs have grown 7.5 times in recent years. In surveys, young people also consistently identify being a creator as a popular career goal. And YouTube has played an outsized role in building the modern creator economy.

It pays to be a popular creator and/or influencer on any platform, but YouTube’s widely regarded as the most lucrative social media site when it comes to direct view-to-payment value. And creators are making more money off of folks watching YouTube on traditional TV sets, rather than mobile devices. The company reported that the number of YouTube channels making more than $100,000 from TV screens rose 45 percent year over year.

Clearly, YouTube isn’t just for streamers anymore. Heck, the platform is broadcasting NFL games — arguably the single biggest product in American culture — with great success. But if you want to make it big as a creator, YouTube remains the place where you can carve out a highly lucrative living.

Massive photo of Trump and Epstein unveiled outside Windsor Castle – National– globalnews.ca
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A massive photograph of Donald Trump and convicted sex offender Jeffrey Epstein has appeared on the lawn outside Windsor Castle, ahead of the U.S. president’s second state visit to the U.K. on Tuesday.

Footage shared by the British political protest organization Everyone Hates Elon shows several people unveiling the blown-up photograph, which the group says was funded by donations from the British public.

Organizers wrote alongside the footage, “Trump is coming to the UK to AVOID the EPSTEIN story. Unfortunately the British public just crowdfunded the WORLD’S BIGGEST PHOTO of Donald with convicted paedophile Jeffrey Epstein.”

“And here it is right outside Windsor Castle, where @realdonaldtrump is staying with the King this week.”

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The King is set to host Trump and the First Lady this week at Windsor Castle, where they will be given a ceremonial welcome and treated to a state banquet.